Why the alpha variant (originally found in the U.K.) has been so strong

Reliable news from professional sources for events outside the USA
Forum rules
The rules to post are simple. Show your work. Post your proof. Cite verified, credible sources. Links to blogs and posting memes are not acceptable and will get you banned. Intelligent, educated, literate people always welcome.
Post Reply
User avatar
AHE
Site Admin
Posts: 3793
Joined: 2020, Sep 14, Mon, 9:56 am

Why the alpha variant (originally found in the U.K.) has been so strong

Unread post by AHE »

They found that lung cells with alpha made drastically less interferon, a protein that switches on a host of immune defenses,” according to The New York Times. “They also found that in the alpha cells, the defensive genes normally switched on by interferon were quieter than in cells infected with other variants.
https://www.deseret.com/coronavirus/202 ... nt-reasons
AHE network of sites

Blog: https://www.arkdvd.com/wp
User avatar
AHE
Site Admin
Posts: 3793
Joined: 2020, Sep 14, Mon, 9:56 am

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

Unread post by AHE »

B.1.1.7 isolates more effectively suppress host innate immune responses in airway epithelial cells. We found that B.1.1.7 isolates have dramatically increased subgenomic RNA and protein levels of Orf9b and Orf6, both known innate immune antagonists. Expression of Orf9b alone suppressed the innate immune response through interaction with TOM70, a mitochondrial protein required for RNA sensing adaptor MAVS activation, and Orf9b binding and activity was regulated via phosphorylation. We conclude that B.1.1.7 has evolved beyond the Spike coding region to more effectively antagonise host innate immune responses through upregulation of specific subgenomic RNA synthesis and increased protein expression of key innate immune antagonists.
https://www.biorxiv.org/content/10.1101 ... 6.446826v1
AHE network of sites

Blog: https://www.arkdvd.com/wp
User avatar
AHE
Site Admin
Posts: 3793
Joined: 2020, Sep 14, Mon, 9:56 am

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

Unread post by AHE »

B.1.1.7 isolates more effectively suppress host innate immune responses in airway epithelial cells. We found that B.1.1.7 isolates have dramatically increased subgenomic RNA and protein levels of Orf9b and Orf6, both known innate immune antagonists. Expression of Orf9b alone suppressed the innate immune response through interaction with TOM70, a mitochondrial protein required for RNA sensing adaptor MAVS activation, and Orf9b binding and activity was regulated via phosphorylation. We conclude that B.1.1.7 has evolved beyond the Spike coding region to more effectively antagonise host innate immune responses through upregulation of specific subgenomic RNA synthesis and increased protein expression of key innate immune antagonists.
https://www.biorxiv.org/content/10.1101 ... 6.446826v1
AHE network of sites

Blog: https://www.arkdvd.com/wp
Post Reply