https://mbio.asm.org/content/mbio/11/5/ ... 0.full.pdfWe show that 80% of our sequences descend from strains that were initially circulating
widely in Europe but have since dominated the outbreak in the United States.
Proof that slowing inbound travel from CHINA was not a significant factor
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Proof that slowing inbound travel from CHINA was not a significant factor
- AHE
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Re: Proof that slowing inbound travel from CHINA was not a significant factor
https://jamanetwork.com/journals/jamane ... le/2771401Such a high proportion of our patients having all 4 variation indicates the seeding of our population by a strain originating in Europe. This finding is further validated in our local phylogenetic tree, which separates into 2 main clusters, our global tree in which our population closely resembles SARS-CoV-2 genomes from New York,9 followed by a smaller percentage from Washington state, together identifying possible routes for the dissemination of SARS-CoV-2 into the Southern California populace.
However, despite our earlier estimates, an even larger portion of our sample population had a significant resemblance to genomes from New York, the epicenter of the SARS-CoV-2 outbreak in the US.9,12,44 The appearance of the majority of our samples within different subclades of New York isolates suggests that SARS-CoV-2 likely spread from multiple introductions from New York.
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